1. Hydrogenation & oxidation in micro-packed bed reactor

Multiphase flow, transport and reaction in micro-packed bed reactor, and the applications in fine chemicals and pharmaceuticals.

2. Continuous flow manufacturing of active pharmaceutical ingredients

API synthesis based on microreactor, such as cross-coupling reactions, Friedel-crafts alkylation reaction, organolithium reaction, photochemical reaction and so on; Automatic synthesis system based on flow technology.

3. In-line sensing & analysis

Based on excellent transport, low reagent consumption and inherent safety properties of micro-devices, we try to develop in-line sensing & analysis system, including in-line analysis of reaction heat, solubility and diffusivity of gas/liquid system, reaction kinetics, etc.

1. Natural Science Foundation of China, major project (Technical experts), 21991103, Micro chemical process and scientific basis for the preparation of energetic and reactive chemicals, 2020.01-2024.12

2. Natural Science Foundation of China, General Project, 21978146, gas-liquid flow and mass transfer intensification in micro packed bed reactor, 2020.1-2023.12

3. Natural Science Foundation of China，Excellent Youth Fund Project, 22022809, Microreactor technology and process intensification, 2021.1- 2023.12

4. Tsinghua University Engineering youth program, 20197050015, continuous hydrogenation of drug molecules in micro packed bed reactor, 2019.8-2020.12

5. Natural Science Foundation of China, Youth Fund Project, 21506110, Miniaturization of Beckmann rearrangement reaction in organic catalytic system, 2016.1-2018.12

6. Postdoctoral Science Foundation, General Project, 2015M570111, Beckmann rearrangement of cyclohexanone oxime catalyzed by organic acids in microreactor.

7. Crosswise tasks and transformation of technological achievements.

2022

1. Duan, X.; Yin, J.; Huang, M.; Wang, P.; Zhang, J. Hydrogenation Kinetics of Halogenated Nitroaromatics over Pt/C in a Continuous Micro-Packed Bed Reactor. Chemical Engineering Science 2022, 251, 117483.

2. Zhang, C.; Duan, X.; Yin, J.; Lou, F.; Zhang, J. Copper/TEMPO-Catalyzed Continuous Aerobic Alcohol Oxidation in a Micro-Packed Bed Reactor. Reaction Chemistry & Engineering 2022, 7 (6), 1289–1296.

3. Ma, C.; Huang, M.; Yin, J.; Lou, F.; Zhang, J. Investigation of Hydrogenation and Mass Transfer Performance in Micropacked Beds with Highly Active Monolithic Catalysts. Chemical Engineering Science 2022, 251, 117477.

4. Chen, J.; Zhou, C.; Xie, B.; Zhang, J. Simulation of the Enhancement of Dean Flow on the Liquid–Liquid Extraction in Membrane Contactors. Separation and Purification Technology 2022, 285, 120384.

5. Duan, X.; Yin, J.; Feng, A.; Huang, M.; Fu, W.; Xu, W.; Huang, Z.; Zhang, J. Continuous Hydrogenation of Halogenated Nitroaromatic Compounds in a Micropacked Bed Reactor. J Flow Chem 2022, 12 (1), 121–129.

6. Duan, X.; Yin, J.; Huang, M.; Feng, A.; Fu, W.; Chen, H.; Huang, Z.; Ding, Y.; Zhang, J. Hydrogenation Kinetics of M-Dinitrobenzene in a Continuous Micro-Packed Bed Reactor. Chemical Engineering Science 2022, 248, 117113.

7. Liang, R.; Duan, X.; Zhang, J.; Yuan, Z. Bayesian Based Reaction Optimization for Complex Continuous Gas–Liquid–Solid Reactions. Reaction Chemistry & Engineering 2022, 7 (3), 590–598.

2021

1. Cao, Q.; Sang, L.; Tu, J.; Xiao, Y.; Liu, N.; Wu, L.; Zhang, J. Rapid Degradation of Refractory Organic Pollutants by Continuous Ozonation in a Micro-Packed Bed Reactor. Chemosphere 2021, 270, 128621.

2. Xie, B.; Zhou, C.; Sang, L.; Ma, X.; Zhang, J. Preparation and Characterization of Microbubbles with a Porous Ceramic Membrane. Chemical Engineering and Processing - Process Intensification 2021, 159, 108213.

3. Xie, B.; Zhou, C.; Huang, X.; Chen, J.; Ma, X.; Zhang, J. Microbubble Generation in Organic Solvents by Porous Membranes with Different Membrane Wettabilities. Ind. Eng. Chem. Res. 2021, 60 (23), 8579–8587.

4. Ma, C.; Sang, L.; Duan, X.; Yin, J.; Zhang, J. An Efficient Method for Enhancing Adhesion and Uniformity of Al2O3 Coatings on Nickel Micro-Foam Used in Micropacked Beds. Chinese Journal of Chemical Engineering 2021, 39, 162–172.

5. Zhou, C.; Xie, B.; Chen, J.; Fan, Y.; Zhang, J. Enhancement of Gas-Liquid Mass Transfer in Curved Membrane Contactors with the Generation of Dean Vortices. Journal of Membrane Science 2021, 636, 119592.

6. Cao, Q.; Lou, F.; Liu, N.; Zhang, J.; Wu, L. Continuous Catalytic Ozonation of Antibiotics Using Mn and Cu Oxides on γ-Al2O3 Pellets in a Micropacked Bed Reactor. ACS EST Water 2021, 1 (8), 1911–1920.

7. Duan, X.; Wang, X.; Chen, X.; Zhang, J. Continuous and Selective Hydrogenation of Heterocyclic Nitroaromatics in a Micropacked Bed Reactor. Org. Process Res. Dev. 2021, 25 (9), 2100–2109.

8. Ma, C.; Duan, X.; Yin, J.-B.; Sang, L.; Zhang, J. Preparation of Pd/Al2O3/Nickel Microfoam Catalysts by Electrodeposition for Hydrogenation in a Micropacked Bed Reactor. Ind. Eng. Chem. Res. 2021, 60 (45), 16522–16532.

2020

1. Sang, L.; Feng, X.; Tu, J.; Xie, B.; Luo, G.; Zhang, J. Investigation of External Mass Transfer in Micropacked Bed Reactors. Chemical Engineering Journal 2020, 393, 124793.

2. Zhang, C.; Zhang, J.; Luo, G. Kinetics Determination of Fast Exothermic Reactions with Infrared Thermography in a Microreactor. J Flow Chem 2020, 10 (1), 219–226.

3. Lin, X.; Zhou, C.; Zhu, S.; Deng, H.; Zhang, J.; Lu, Y. O2-Tuned Protein Synthesis Machinery in Escherichia Coli-Based Cell-Free System. Frontiers in Bioengineering and Biotechnology 2020, 8.

4. Duan, X.; Tu, J.; R. Teixeira, A.; Sang, L.; F. Jensen, K.; Zhang, J. An Automated Flow Platform for Accurate Determination of Gas–Liquid–Solid Reaction Kinetics. Reaction Chemistry & Engineering 2020, 5 (9), 1751–1758.

5. Zhou, C.; Xie, B.; Li, S.; Zhang, J. Rapid Measurement of Gas Diffusivity in Liquids Using a Tube-in-Tube Reactor with an Unsteady-State Strategy. AIChE Journal 2020, 66 (11), e17015.

6. Tu, J.; Sang, L.; Cheng, H.; Ai, N.; Zhang, J. Continuous Hydrogenolysis of N-Diphenylmethyl Groups in a Micropacked-Bed Reactor. Org. Process Res. Dev. 2020, 24 (1), 59–66.

7. Zhou, C.; Lin, X.; Lu, Y.; Zhang, J. Flexible On-Demand Cell-Free Protein Synthesis Platform Based on a Tube-in-Tube Reactor. React. Chem. Eng. 2020, 5 (2), 270–277.

8. Sang, L.; Tu, J.; Cheng, H.; Luo, G.; Zhang, J. Hydrodynamics and Mass Transfer of Gas–Liquid Flow in Micropacked Bed Reactors with Metal Foam Packing. AIChE Journal 2020, 66 (2), e16803.

9. Du, C.; Wang, P.; Hu, Y.; Zhang, J.; Luo, G. Liquid–Liquid Mass Transfer Enhancement in Milliscale Packed Beds. Ind. Eng. Chem. Res. 2020, 59 (9), 4048–4057.

10. Zhang, H.; Kopfmüller, T.; Achermann, R.; Zhang, J.; Teixeira, A.; Shen, Y.; Jensen, K. F. Accessing Multidimensional Mixing via 3D Printing and Showerhead Micromixer Design. AIChE Journal 2020, 66 (4), e16873.

2019

1. Lan, M.; Zhao, Z.; Zeng, Q.; Zhou, C.; Zhang, J. Rapid Measurement of Gas Solubility in Ionic Liquids with a Simple Tube-in-Tube Reactor. Ind. Eng. Chem. Res. 2019, 58 (16), 6696–6703.

2. Zhang, J.; Teixeira, A. R.; Zhang, H.; Jensen, K. F. Flow Toolkit for Measuring Gas Diffusivity in Liquids. Anal. Chem. 2019, 91 (6), 4004–4009.

3. Du, C.; Zhang, J.; Li, L.; Wang, K.; Luo, G. A Modified Mixed-Acid Catalytic System for Beckmann Rearrangement of Cyclohexanone Oxime. AIChE Journal 2019, 65 (6), e16603.

4. Deng, J.; Zhang, J.; Wang, K.; Luo, G. Microreaction Technology for Synthetic Chemistry. Chinese Journal of Chemistry 2019, 37 (2), 161–170.

5. Du, C.; Hu, Y.; Zhang, J.; Luo, G. Ultra-Low Formation of Octahydrophenazine in the Beckmann Rearrangement of Cyclohexanone Oxime Using a Microreactor. React. Chem. Eng. 2019, 4 (11), 1991–1999.

6. Li, L.; Zhang, J.; Du, C.; Luo, G. Intensification of the Sulfuric Acid Alkylation Process with Trifluoroacetic Acid. AIChE Journal 2019, 65 (1), 113–119.

2018

1. Zhang, J.; Teixeira, A. R.; Jensen, K. F. Automated Measurements of Gas-Liquid Mass Transfer in Micropacked Bed Reactors. AIChE Journal 2018, 64 (2), 564–570.

2. Du, C.; Zhang, J.; Luo, G. Organocatalyzed Beckmann Rearrangement of Cyclohexanone Oxime in a Microreactor: Kinetic Model and Product Inhibition. AIChE Journal 2018, 64 (2), 571–577.

3. Navarro-Brull, F. J.; Teixeira, A. R.; Zhang, J.; Gómez, R.; Jensen, K. F. Reduction of Dispersion in Ultrasonically-Enhanced Micropacked Beds. Ind. Eng. Chem. Res. 2018, 57 (1), 122–128.

4. Navarro-Brull, F. J.; Teixeira, A. R.; Zhang, J.; Gómez, R.; Jensen, K. F. Reduction of Dispersion in Ultrasonically-Enhanced Micropacked Beds. Ind. Eng. Chem. Res. 2018, 57 (1), 122–128.

2017

1. Zhang, J.; Teixeira, A. R.; Zhang, H.; Jensen, K. F. Automated in Situ Measurement of Gas Solubility in Liquids with a Simple Tube-in-Tube Reactor. Anal. Chem. 2017, 89 (16), 8524–8530.

2. Du, C.; Zhang, J.; Li, L.; Wang, K.; Luo, G. Impurity Formation in the Beckmann Rearrangement of Cyclohexanone Oxime to Yield ε-Caprolactam. Ind. Eng. Chem. Res. 2017, 56 (48), 14207–14213.

3. Zhang, J.; Wang, K.; Teixeira, A. R.; Jensen, K. F.; Luo, G. Design and Scaling Up of Microchemical Systems: A Review. Annual Review of Chemical and Biomolecular Engineering 2017, 8 (1), 285–305.

4. Lin, X.; Yan, S.; Zhou, B.; Wang, K.; Zhang, J.; Luo, G. Highly Efficient Synthesis of Polyvinyl Butyral (PVB) Using a Membrane Dispersion Microreactor System and Recycling Reaction Technology. Green Chem. 2017, 19 (9), 2155–2163.

2016

1. Zhang, J.; Wang, K.; Zhang, C.; Luo, G. Safety Evaluating of Beckmann Rearrangement of Cyclohexanone Oxime in Microreactors Using Inherently Safer Design Concept. Chemical Engineering and Processing: Process Intensification 2016, 110, 44–51.

2. Zhang, J.; Zhang, C.; Liu, G.; Luo, G. Measuring Enthalpy of Fast Exothermal Reaction with Infrared Thermography in a Microreactor. Chemical Engineering Journal 2016, 295, 384–390.

3. Zhang, C.; Zhang, J.; Luo, G. Kinetic Study and Intensification of Acetyl Guaiacol Nitration with Nitric Acid—Acetic Acid System in a Microreactor. Journal of Flow Chemistry 2016, 6 (4), 309–314.

4. Wang, P.; Zhang, J.; Wang, K.; Luo, G.; Xie, P. Kinetic Study of Reactions of Aniline and Benzoyl Chloride Using NH3 as Acid Absorbent in a Microstructured Chemical System. Ind. Eng. Chem. Res. 2016, 55 (22), 6310–6316.

5. Lin, X.; Zhang, J.; Wang, K.; Luo, G. Determination of the Micromixing Scale in a Microdevice by Numerical Simulation and Experiments. Chemical Engineering & Technology 2016, 39 (5), 909–917.

6. Li, L.; Zhang, J.; Wang, K.; Xu, J.; Luo, G. Droplet Formation of H2SO4/Alkane System in a T-Junction Microchannel: Gravity Effect. AIChE Journal 2016, 62 (12), 4564–4573.

7. Li, L.; Zhang, J.; Shen, C.; Wang, Y.; Luo, G. Oxidative Desulfurization of Model Fuels with Pure Nano-TiO2 as Catalyst Directly without UV Irradiation. Fuel 2016, 167, 9–16.

2015

1. Zhang, J.; Dong, C.; Du, C.; Luo, G. Organocatalyzed Beckmann Rearrangement of Cyclohexanone Oxime in a Microchemical System. Org. Process Res. Dev. 2015, 19 (2), 352–356.

2. Wang, P.; Wang, K.; Zhang, J.; Luo, G. Preparation of Poly( p -Phenylene Terephthalamide) in a Microstructured Chemical System. RSC Advances 2015, 5 (79), 64055–64064.

3. Wang, P.; Wang, K.; Zhang, J.; Luo, G. Non-Aqueous Suspension Polycondensation in NMP-CaCl2/Paraffin System — A New Approach for the Preparation of Poly(p-Phenylene Terephthalamide). Chin J Polym Sci 2015, 33 (4), 564–575.

4. Wang, P.; Wang, K.; Zhang, J.; Luo, G. Kinetic Study of Reactions of Aniline and Benzoyl Chloride in a Microstructured Chemical System. AIChE Journal 2015, 61 (11), 3804–3811.

5. Wang, K.; Zhang, J.; Zheng, C.; Dong, C.; Lu, Y.; Luo, G. A Consecutive Microreactor System for the Synthesis of Caprolactam with High Selectivity. AIChE Journal 2015, 61 (6), 1959–1967.

6. Lu, Y.; Xin, D.; Zhang, J.; Luo, G. Modeling Ethyl Diazoacetate Synthesis in an Adiabatic Microchemical System. Chemical Engineering Journal 2015, 273, 406–412.

7. Lu, Y.; Wang, R.; Zhang, J.; Jin, Q.; Luo, G. Evaluation of an Improved Epichlorohydrin Synthesis from Dichloropropanol Using a Microchemical System. Chinese Journal of Chemical Engineering 2015, 23 (7), 1123–1130.

8. Lin, X.; Wang, K.; Zhang, J.; Luo, G. Process Intensification of the Synthesis of Poly(Vinyl Butyral) Using a Microstructured Chemical System. Ind. Eng. Chem. Res. 2015, 54 (14), 3582–3588.

9. Lin, X.; Wang, K.; Zhang, J.; Luo, G. Liquid–Liquid Mixing Enhancement Rules by Microbubbles in Three Typical Micro-Mixers. Chemical Engineering Science 2015, 127, 60–71.

10. Dong, C.; Wang, K.; Zhang, J.; Luo, G. Reaction Kinetics of Cyclohexanone Ammoximation over TS-1 Catalyst in a Microreactor. Chemical Engineering Science 2015, 126, 633–640.

2014＆Before

1. Zhang, J.; Wang, K.; Lin, X.; Lu, Y.; Luo, G. Intensification of Fast Exothermic Reaction by Gas Agitation in a Microchemical System. AIChE Journal 2014, 60 (7), 2724–2730.

2. Zhang, J.; Riaud, A.; Wang, K.; Lu, Y.; Luo, G. Beckmann Rearrangement of Cyclohexanone Oxime to ε-Caprolactam in a Modified Catalytic System of Trifluoroacetic Acid. Catal Lett 2014, 144 (1), 151–157.

3. Dong, C.; Zhang, J.; Wang, K.; Luo, G. Micromixing Performance of Nanoparticle Suspensions in a Micro-Sieve Dispersion Reactor. Chemical Engineering Journal 2014, 253, 8–15.

4. Zhang, J.; Lu, Y.; Wang, K.; Luo, G. Novel One-Step Synthesis Process from Cyclohexanone to Caprolactam in Trifluoroacetic Acid. Ind. Eng. Chem. Res. 2013, 52 (19), 6377–6381.

5. Zhang, J.; Wang, K.; Lu, Y.; Luo, G. Beckmann Rearrangement of Cyclohexanone Oxime in a Microchemical System: The Role of SO3 and Product Inhibition. AIChE Journal 2012, 58 (10), 3156–3160.

6. Zhang, J.; Wang, K.; Lu, Y.; Luo, G. Beckmann Rearrangement in a Microstructured Chemical System for the Preparation of ε-Caprolactam. AIChE Journal 2012, 58 (3), 925–931.

7. Zhang, J.; Lu, Y.; Jin, Q.; Wang, K.; Luo, G. Determination of Kinetic Parameters of Dehydrochlorination of Dichloropropanol in a Microreactor. Chemical Engineering Journal 2012, 203, 142–147.

8. Zhang, J.; Tan, J.; Wang, K.; Lu, Y.; Luo, G. Chlorohydrination of Allyl Chloride to Dichloropropanol in a Microchemical System. Ind. Eng. Chem. Res. 2012, 51 (45), 14685–14691.

9. Tan, J.; Zhang, J.; Lu, Y.; Xu, J.; Luo, G. Process Intensification of Catalytic Hydrogenation of Ethylanthraquinone with Gas-Liquid Microdispersion. AIChE Journal 2012, 58 (5), 1326–1335.

10. Zhang, J.; Wang, K.; Lu, Y.; Luo, G. Characterization and Modeling of Micromixing Performance in Micropore Dispersion Reactors. Chemical Engineering and Processing: Process Intensification 2010, 49 (7), 740–747.

1. Natural Science Foundation of China, Excellent youth fund.

2. Journal of Flow Chemistry “Emerging Investigators”,2019

3. Ind. & Eng. Chem. Res “Influential Researchers”,2019

4. Excellent Doctoral Dissertation of Tsinghua University, 2014

5. Excellent graduates of Beijing, 2014

6. Excellent college counselors in Beijing, 2014

7. Ministry of Education’s Academic Youth Award for Doctoral Candidate, 2012

8. Excellent graduates of Tsinghua University, Merit student in Beijing, 2009

Doctor（graduate year）

Caijin Zhou（2022）

Graduation Project（project year）：

Minle Lan (2018), Qingqiulin Zheng (2018), Yunfan Zhu (2021), Yiwei Fan (2022)

Visiting student

Jiacheng Tu, 2018-2020

Qiang Cao, 2019-2021

Xiaoting Huang, 2019-2021

Fengyan Lou, 2020-2022